SYSTEMIC INFLAMMATORY MARKERS IN PATIENTS WITH STAGE III AND IV PERIODONTITIS: CORRELATION WITH CARDIOVASCULAR RISK
DOI:
https://doi.org/10.56238/revgeov17n3-003Keywords:
Stage III and IV Periodontitis, Systemic Inflammatory Markers, Cardiovascular Risk, Endothelial DysfunctionAbstract
Stage III and IV periodontitis represents a chronic inflammatory condition of high prevalence, with documented systemic repercussions that extend beyond the oral cavity. This study analyzes the relationships between systemic inflammatory markers present in patients with severe periodontitis and cardiovascular risk indicators recorded in the scientific literature, with the objective of consolidating evidence on the biological mechanisms connecting the two conditions. The research adopts a qualitative approach of bibliographic nature, with an exploratory and descriptive design, based on a systematic survey in the PubMed/MEDLINE, Scopus, Web of Science, SciELO and VHL databases, covering the period between 2011 and 2026. The results indicate that patients with stage III and IV periodontitis present consistent elevations of C-reactive protein, pro-inflammatory interleukins and oxidative stress markers, forming a dose-response pattern between periodontal severity and the intensity of the systemic inflammatory response. Active periodontal treatment produces measurable reductions in these markers over time. It is concluded that severe periodontitis operates as a modifiable cardiovascular risk factor, which supports the need for integrated clinical protocols between dentistry and medicine, recognizing oral health as an integral component of systemic health management and cardiovascular prevention strategies.
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