BIOCOMPATIBILITY OF ALTICRN+SI3N4 PROSTHETIC COATING IN A SUBCUTANEOUS ANIMAL MODEL OF MICE
DOI:
https://doi.org/10.56238/revgeov16n5-097Keywords:
Nanotechnology, Coating, ImplantAbstract
Nanotechnology used as a coating for orthopedic, neurological, and dental implants is increasingly important for their fixation and durability. Biocompatibility with bone tissue is therefore essential. After evaluating the results through histological analysis of 46 subcutaneous tissue samples from mice with and without AlTiCrN+Si3N4 coating (Titanium Aluminum Nitride enveloped in a silicon nitride layer), it was found that eosinophilic infiltration, intensity of the inflammatory process, and infiltration by multinucleated giant cells showed no statistical difference between the two groups. Fibrosis was found in the coated group, which was 1.7 times greater (RR = 1.7, 95% CI = 0.83 to 3.7), and the presence of black granular pigment characterized wear, displacement, and/or corrosion of the coating in all samples. It is concluded that such material has no space to be used in nanotechnological coatings of metal implants.
Downloads
References
1. KUMAR S.S.D., ABRAHAMSE H., Rewiew Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications. Int. J. Mol. Sci. 2020, 21, 6752; doi:10.3390/ijms 21186752
2. SILVEIRA S.R.; SAHM B.D.; KREVE S.; REIS A.C.; Osseointegration, antimicrobial capacity and cytotoxicity of implant materials coated with graphene compounds: A systematic review. Japanese Dental Science Review 59 (2023) 303–311
3. BOMFIM V.V.B.S. ET COLS. Inovações em cirurgia ortopédica: Avanços tecnológicos e estratégias para recuperação pós operatória. Rev. Ïbero Americanas humanidades, ciência e Educação. Sao Paulo, V 9 n 12 dez. 2023
4. NAVARRO M., MICHIARDI A., CASTAÑO O., PLANELL J.A. Biomaterials in Orthopaedics. J. R. Soc. Interface 2008(5), 1137-1158.
5. DIAS R.C., KISAKI Y., UNGARETTI A., BREDEMEIER F., TARRAGÔ R., SCHWARTSMANN C.R. Estudo Experimental da Reação Tecidual Óssea ao Titânio Ti6A14V Recoberto com Hidroxiapatita. Rev Bras de Ortopedia e Traumatologia. 1993, Junho.
6. LAZARINIS S., KÄRRHOLM J., HAILER N.P. Effects of Hydroxyapatite Coating on Survival of an Uncemented Femoral Stem. Acta Orthopaedica 2011; 82 (4): 399–404.
7. CATALIN M., ADRIAN P., STANCA C. Selection of biomaterials for orthopaedic applications using the ponderated properties method. The romanian review precision mechanics, optics & mechatronics, 2009 (19), 36.
8. VOIGT J.D., MOSIER M. Hydroxyapatite (HA) coating appears to be of beneit for implant durability of tibial components in primary total knee arthroplasty. Acta Orthopaedica 2011; 82 (4): 448–459
9. SILVA V.V. Aplicação de biomateriais em ortopedia e engenharia de tecido ósseo. Rev Saúde Meio Ambiente. 2017;5(2):14-27.
10. RODRIGUES L.B. Aplicações de biomateriais em ortopedia. Estudos Tecnológicos em Engenharia. 2013;9(2):63-76.
11. COSTA T.O.A, DONATO NETO E.P., SENA A.J.G., GUIMARÃES A.L.S. Uso de biomateriais e técnicas regenerativas em cirurgias ortopédicas. Brazilian Journal of Implantology and Health Sciences. 2024;6(11):3104-3112.
