EFECTOS DEL ABURRIMIENTO EN EL SISTEMA INMUNE HUMANO Y SUS POSIBLES INTERVENCIONES FARMACOLÓGICAS
DOI:
https://doi.org/10.56238/revgeov17n2-048Palabras clave:
Aburrimiento, Sistema Inmunitario, Psiconeuroinmunología, Cortisol, Intervenciones FarmacológicasResumen
El estado emocional, específicamente el aburrimiento, influye en el sistema inmunitario humano a través de mecanismos neurobiológicos que vinculan el estrés psicológico con la activación de hormonas como el cortisol. Este estudio explora la interrelación entre el aburrimiento crónico y la función inmunitaria, analizando estrategias farmacológicas para mitigar sus efectos perjudiciales. Se realizó una revisión bibliográfica integrativa en las bases de datos PubMed, Scielo, Google Scholar y Web of Science (2019-2024). Los resultados indican que el aburrimiento persistente eleva los niveles de cortisol, lo cual suprime la respuesta inmunológica y fomenta comportamientos de riesgo, como el sedentarismo. Aunque las intervenciones con antidepresivos y ansiolíticos muestran potencial en la regulación emocional e inmunológica indirecta, el estudio concluye que es necesaria una perspectiva terapéutica integrativa. La promoción del bienestar emocional y las estrategias psicosociales son fundamentales para el mantenimiento de la salud inmunológica.
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Referencias
BORGES, A. L. V.; SANTOS, R. M., LIMA, C. L. “Estresse e sistema imunológico: Interações e implicações para a saúde”. Revista Brasileira de Terapias Cognitivas, vol. 15, n. 2, 2019.
DHABHAR, F. S. “Effects of stress on immune function: The good, the bad, and the beautiful”. Immunology and Allergy Clinics of North America, vol. 38, n. 3, maio, 2014.
EASTWOOD, J. D., FRISCHEN, A., FENSKE, M. J., & SMILEK, D. “The unengaged mind: Defining boredom in terms of attention”. Perspectives on Psychological Science, vol. 7, n. 5, setembro, 2012.
FAHLMAN, S. A.; MERCER-LYNN, K. B.; FLORA, D. B., EASTWOOD, J. D. “Development and validation of the Boredom Proneness Scale”. Personality and Individual Differences, vol. 55, n. 2, fevereiro, 2013.
FISHER, A. J.; ESLER, M. D. “The impact of boredom on health: Implications for treatment and prevention”. Psychology & Health, vol. 34, n. 5, 2019.
HARRIS, M. B., FOULKES, L.; WRIGHT, A. “Boredom in adolescence: The role of identity and exploration”. Journal of Youth and Adolescence, vol. 50, n. 4, 2021.
JOHNSON, M.; LEE, K. “Boredom and stress: Neurobiological pathways and implications for health”. Frontiers in Psychology, vol. 14, 2023.
KATZUNG, B. G.; VANDERAH, T. W. Farmacologia básica e clínica. 15. ed. Porto Alegre: Artmed, 2022.
KOLLINS, S. H., et al. “Pharmacological approaches to the treatment of attention-deficit hyperactivity disorder in adults”. Expert Review of Neurotherapeutics, vol. 19, n. 5, 2019.
MEYER, J. H., et al. “The role of benzodiazepines in the management of anxiety: A review”. Psychiatry Research, vol. 284, 2020.
MILLER, A. H., et al. “Immune dysregulation in depression and its treatment: A review”. Journal of Neuropsychiatry and Clinical Neurosciences , vol. 29, n. 4, 2017.
OLIVEIRA, M. S., ALMEIDA, F. S.; FREITAS, J. P. “Impacto do estresse emocional na imunidade: Uma revisão”. Jornal Brasileiro de Psicologia, vol. 73, n. 1, 2021.
PIRES, G., & ALMEIDA, R. “Pharmacological interventions for emotional regulation: Implications for immune function”. Psychopharmacology, vol. 240, n. 5, 2023.
ROCHAT, P., DENEAULT, A.; DUMAS, C. “The role of boredom in childhood development”. Child Development Perspectives, vol. 14, n. 3, 2020.
RODRIGUES, C., FERREIRA, L.; MENDES, A. “The interplay between emotional states and immune response: A focus on pharmacological treatments”. Clinical Psychopharmacology and Neuroscience, vol. 20, n. 3, 2022.
RADAKOVICH, M. et al. “Apathy in cognitive disorders: a neuropsychological perspective”. Journal of Neuropsychiatry, vol. 27, n. 2, 2015.
MARIANI, M. et al. “Apathy in neurodegenerative diseases: clinical and neurobiological aspects”. Neurology International, vol. 13, n. 4,, 2021.
MARIN, R. S. et al. “Apathy: A neuropsychiatric syndrome”. The Journal of Neuropsychiatry and Clinical Neurosciences, vol. 3, n. 3, 1991.
WEINER, M. F. et al. “Neuropsychiatric syndromes in Alzheimer’s disease: results from the National Alzheimer’s Coordinating Center”. Alzheimer’s & Dementia: the journal of the Alzheimer’s Association, vol. 2, n. 2, 2006.
GENTIL, V. et al. “A medicalização do sofrimento na modernidade: reflexões sobre o discurso psiquiátrico contemporâneo”. Revista Latinoamericana de Psicopatologia Fundamental, vol. 10, n. 2, 2007.
ELLIOTT, R. et al. “Dopaminergic effects on human cognitive performance: A double-blind, placebo-controlled study”. Psychopharmacology, vol. 131, n. 2, 1997.
MEHTA, M. A. et al. “Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain”. Journal of Neuroscience, vol. 20, n. 6, 2000.
SILVA, J. P. et al. “Metilfenidato no tratamento da apatia no idoso”. Revista Brasileira de Geriatria e Gerontologia, vol. 24, n. 3, 2021.
SANDI, C., HALLER, J.; PASKÁ, M. “Boredom and its consequences: A developmental perspective”. Psychology of Emotion, vol. 38, n. 2, 2019.
SEGERSTROM, S. C.; MILLER, G. E. “Psychological stress and disease”. JAMA, .vol. 298, n. 14, outubro, 2007.
SCHWARTZE, Manuel et al. “Boredom makes me sick: adolescents’ boredom trajectories and their health-related quality of life”. International Journal of Environmental Research and Public Health, v. 18, junho, 2021.
SMITH, J., BROWN, A.; WHITE, D. “Understanding the psychological effects of boredom on immune health”. Health Psychology Review, vol. 15, n. 1, 2021.
THOMPSON, L. “Boredom as a stressor: Implications for health and well-being”. Journal of Health Psychology, vol. 27, n. 4, 2022.
YAZBEK, H. et al. “L’apathie dans la schizophrénie: une revue clinique et critique de la question”. L'Encéphale, v. 40, n. 3, junho, 2014.
