HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS SECONDARY TO VISCERAL LEISHMANIASIS: CASE REPORT

Abstract

Introduction: Hemophagocytic Lymphohistiocytosis (HLH), or Hemophagocytic Syndrome (HHS), is a rare and serious condition caused by excessive activation of the immune system, manifesting as persistent fever, pancytopenia, and multisystem dysfunction. The secondary form, associated with infections and neoplasms, presents a diagnostic challenge in adults. The association of HLH with visceral leishmaniasis is uncommon and poorly described, requiring clinical reports. Objectives: To describe the clinical, laboratory, and diagnostic aspects of a case of HLH secondary to visceral leishmaniasis in an adult patient. Study design: This is a case report, which will be carried out through the analysis of medical records and results of hematological laboratory tests, as well as an interview with the patient. Therefore, secondary data sources will be used (medical records, radiographs, demographic data, and others). This is a 47-year-old male patient with systemic arterial hypertension and irregular medication use. The project will be registered on the Plataforma Brasil platform and submitted to the Research Ethics Committee (CEP) of the Centro Universitário de Caratinga - UNEC, which issued a favorable approval. The study will begin after CEP approval and will be conducted in accordance with the fundamental principles of Resolution 466/12 of the National Health Council (CNS), which deals with the Guidelines and Standards for Research Involving Human Beings. Those responsible for the research will commit to it through the Researcher Commitment Form. The information in this project and in the data collection will be kept confidential with the signing of the Informed Consent Form.